Dr. Xiaodi Han – Director of Neurosurgery Department at Tiantan Puhua Hospital

Dr. Han Xiaodi is Director of the Nuerolosurgery Department at Tiantan Puhua Hospital, and is renowned worldwide for being one of the leaders in performing successful stem cell surgeries and therapies for patients suffering from a number of neurological disorders.  His work has directly assisted scores of patients to improve their quality of life in ways unmatched by Western countries.  His past research has focused on clinical management of brain tumors and cerebral aneurysms, chemotherapy of malignant gliomas, the application of neuronavigation systems during operations, and using neural stem cells in the treatment of neurodegeneration diseases and trauma patients.  He has received awards as the Chinese National Science and Technology prize winner for his work on surgical treatment of giant cerebral aneurysms and also won the Beijing Science and Technology Prize for his publications on minimal invasive neurosurgery. 

Previous to coming over to Tiantan Puhua, Dr. Han worked in the Department of Neurosurgery at the Alfred Hospital in Melbourne Australia.  Before this, he was Neurosurgeon and Researcher in the Department of Neurosurgery at the larger neighbor Tiantan Hospital. He was also a volunteer neurosurgeon at the No. 2 Red Hill Hospital in Inner Mongolia in China’s far North.  Dr. Han received his medical degree from Shanghai Medical University, which is now a part of China’s top science institution, Fudan University.  He received his PhD from Capital University of Medical Sciences in Beijing with a thesis related to nerve cell genetic makeup and their correlations with magnetic resonance imaging and pathology in gliomas. 

Education:

1986-1992: Medical Degree: Shanghai Medical University (now merged into Fudan University)
1992-1997: Neurosurgeon training
1997-2000: PhD Degree: Capital University of Medical Sciences. PhD thesis: Study on the Expression of VEGF, TSP and Their Related Genes Correlated With MR Image and Pathology in Gliomas

Working Experiences:

August 1992- September 2003: Neurosurgeon and Researcher: Department of Neurosurgery, Beijing Tiantan Hospital & Beijing Neurosurgical Institute, Beijing, China.
March 2003-April 2003: Volunteer neurosurgeon, 2nd Red Hill hospital, Inner Mongolia, China
September 2003-2005: Research Fellow: Department of Neurosurgery, The Alfred Hospital, Melbourne, Australia
2005-present: Deputy director, Neurosurgery Department , Beijing Tiantan Puhua Hospital, Beijing.

Research Experiences:

Clinical Research:
From1994: Clinical Management of Brain tumor and Cerebral Aneurysm (see publication)
1997-2003: The Chemotherapy of Malignant Gliomas combined with Surgical Resection.（See the related publications）
1998-2003: The application of neuronavigation system during operation (intraoperative ultrasound application) 
2000-2003: Tumor vaccine in treatment of malignant glioma patients
2003-present: Neural Stem cell in the treatment of neurodegeneration disease and trauma patients.
Basic Research:
1997—2003：Angiogenesis and some related genes expression in gliomas, including oncogene and tumor suppression gene, such as P53, PCNA, VEGF, TSP1,TSP2 etal.
        2003-present: Characteristics and Enhancement of Neurogenesis (endogenous neural stem cell proliferation and migration and differentiation)  after Experiment Trauma Brain Injury

Memberships:
 Chinese Medical Association (Neurosurgery specialty societies)
 Chinese Anti-cancer Association
 Chinese Medical Doctor Association
 Chinese Neuroscience Society 

Prize and Awards:

1. 2nd award of Chinese National Science and Technology prize (2002): Surgical treatment of giant cerebral aneurysms and AVMs (co-author)
2 .First award of Beijing Science and Technology Prize (2004): minimal invasive neurosurgery (Co-author)
3. Excellent staff of the Year (1995): Beijing Tiantan Hospital

1997-2000: RMB 20,000 Beijing Tiantan Hospital Grant for Young Neurosurgeon Research (China): The angiogenesis of cerebral gliomas.
1996-2001: RMB 800,000 National Science and technology fund (China): Surgical Treatment of Giant cerebral aneurysm and AVMs.
1998-2003: RMB 2,000,000 Beijing Government Science and technology fund (China): minimal invasive neurosurgery research
2004: $4,600 Alfred Research Trusts Small Project Grants. Impact of inflammatory cytokines and neurotrophic factors on neurogenesis occurring after experimental traumatic brain injury.
2005-2008: RMB100,000 ($16,000)/year. Beijing Science and technology Committee international cooperation fund (China): Induction of endogenous stem cells to repair brain damage after trauma.

Book:

Hand Book of Neurosurgery (Chinese version) (co-translator):  Shandong Science & Technology Press, 2004

Papers published and Presentations:

1.Cerebral aneurysm associated with von-Recklinghausen’s neurofibromatosis: A case report. Surg Neurol 1998: 50; 592-596
2.Efficacy and toxicity evaluation of fotemustine administered intravenously after surgical resection in adult patients with supratentorial malignant glioma. International Journal of  Medicine (Chinese)，1999，3(12); 16-19
3. Cauda equina tumors: Chin J Neurosurg 1998: 14(6), 328-330
4. Intra-artery infusion of RMP-7 may increase the permeability of BTB。China Medical Tribune，Dec, 1997.
5. The markers which can evaluate the prognosis of astrocytic gliomas.China Medical Tribune,May,1997.
6. A special type of meningioma。China Medical Tribune，Oct. 1997.
7. Primary pulmonary menigiomas. China Medical Tribune，March, 1998.
8. Dissemination of supratentorial malignant gliomas via the cerebrospinal fluid (review). Foreign Medical Sciences Section on Neurology and Neurosurgery, 2001: 28(2), 128-131
Combination of Intraoperative Embolization with Surgical Resection for Treatment of Giant Cerebral AVMs. J. Neurosurg.2001, 94: 158A-159A.
Neuronavigation on Low-grade Glioma Surgery. (presentation on the 2nd Chinese Congress on Minimally Invasive Neurosurgery. Held in Shanghai, March 28-30,2001).
11.The expression of thrombospondine1(TSP1) and thrombospondine2 (TSP2) mRNA and their correlated with microvessels density in gliomas.(In: Proceedings of the World Federation of Neurosurgical Societies 12th World Congress of Neurosurgery. Sydney September 2001)
12.Intraoperative real-time ultrasound combine with MRI navigation system in resection of deep-seated brain lesions. (2003 Xi’an International Neurosurgery Symposium,China)
13. The supraorbital keyhole approach with eyebrow incisions for treating lesionsin the anterior fossa and sellar region. CHINESE MEDICAL JOURNAL (Eng). 2004,117 (3) 323-326
14. Clinical features and minimally invasive surgery of insular lesions: report of 42 cases  CHINESE MEDICAL JOURNAL (Eng). 2004, 117(7), 1104-1108
15. Efficacy evaluation of fotemustine administered in adult patients with supratentorial malignant glioma CHINESE PHARMACEUTICAL JOURNAL (Chinese) 2004, 39 (10), 788-790
16. Different expression of VEGF receptor KDR and FLT-1 mRNA and its correlation with pathology of gliomas BEIJING MEDICAL JOURNAL (Chinese) 2004, 26 (1) 10-13
17. De novo proliferation following diffuse traumatic axonal injury in rats ( poster in 7th International Neurotrauma Symposium 2004, Adelaide)