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资料来源：
Am J Epidemiol. 2007 Apr 1;165(7):794-801.
口服避孕药、生殖因素与女性患者结肠癌危险的前瞻性队列研究
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网址：http://370.daifumd.com 译者：周太成
目的：一直以来,关于使用口服避孕药与结肠癌危险间的关系没有定论。作者在这项大规模前瞻性队列研究中，评估使用口服避孕药及生殖因素(包括产次、初产年龄、月经初潮年龄以及绝经年龄)与结肠癌危险间的关系。
方法：该研究纳入39680例可提供可靠口服避孕药使用情况和结肠癌潜在危险因素相关资料的患者，利用COX比例风险回归模型来确定相对风险度和95%置信区间。所有p值都为双向。
结果：平均随访11年(1992-2004年)的结果显示,267例患者发生结直肠癌。曾经使用过口服避孕药与较低结直肠癌危险相关(相对危险为0.67，95%置信区间：0.5，0.89)。使用口服避孕药时间为6个月至3年的患者与从未使用过的患者相比,相对危险为0.61（95%置信区间：0.40，0.94）。但更长时间使用口服避孕药并未带来相对危险的进一步降低(P=0.09)。生殖因素与结肠癌危险间无显著相关性。
结论：口服避孕药具有降低结直肠癌危险的潜在作用。
Am J Epidemiol. 2007 Apr 1;165(7):794-801. Epub 2007 Jan 10. Links
Oral contraceptives, reproductive factors, and risk of colorectal cancer among women in a prospective cohort study.
Lin J, Zhang SM, Cook NR, Manson JE, Buring JE, Lee IM.
Division of Preventive Medicine, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, MA 02215, USA. jhlin@rics.bwh.harvard.edu
Previous findings on the associations between oral contraceptive (OC) use and reproductive factors and risk of colorectal cancer have been inconclusive. The authors evaluated associations of OC use and reproductive factors (including parity, age at first birth, age at menarche, and age at menopause) with risk of colorectal cancer among women in a large-scale prospective cohort study. The analysis included 39,680 participants in the Women´s Health Study who had usable information on ever use of OCs and potential risk factors for colorectal cancer. Relative risks and 95% confidence intervals were estimated from Cox proportional hazards regression models. All p values were two-sided. During an average of 11 years of follow-up (1992-2004), 267 incident cases of colorectal cancer were documented. Ever use of OCs was associated with a lower risk of colorectal cancer (relative risk = 0.67, 95% confidence interval: 0.50, 0.89). Women who had used OCs for 6 months-<3 years had a relative risk of 0.61 (95% confidence interval: 0.40, 0.94) relative to never users, with little additional decreased risk being seen with longer duration of use (p for multivariate trend = 0.09). No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer.
PMID: 17215381 [PubMed - in process]
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